Department of Internal Medicine and Clinical Nutrition, University of Gothenburg, Goteborg, Sweden. Department of Endocrinology, Sahlgrenska University Hospital, Goteborg, Sweden. School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden. Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden. Department of Internal Medicine and Clinical Nutrition, University of Gothenburg, Goteborg, Sweden oskar.ragnarsson@medic.gu.se. Wallenberg Center for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden.